Nitsa River (Russian: Ница́) is a river in the Sverdlovsk Oblast in Russia. It is a tributary of the Tura. The river commences at the junction of the Neyva and the Rezh, east of the city Alapayevsk and flows firstly in an easterly and then in southeasterly direction. It has a length of 262 kilometres. However, if the Nitsa and Nev'ya are counted as one the river a length of 556 kilometres. The Nitsa converges with the Tura at East-Nitsinskov.
The river has a mixed supply, which is dominated by snow. It has a catchment of 22 300 km². The flow at 165 kilometres from the start, at the city of Irbit is 42.5 m³/sec. The river is usually frozen by the end of October, beginning of November until the end of April. The river is navigable along its entire length. The most important tributaries are the Irbit, which joins at the city of the same name.